The Lancet Handbook of Essential Concepts in Clinical Research (The Lancet Handbooks)
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Comparative efficacy and acceptability of 21 ~ All antidepressants were more efficacious than placebo in adults with major depressive disorder Smaller differences between active drugs were found when placebocontrolled trials were included in the analysis whereas there was more variability in efficacy and acceptability in headtohead trials These results should serve evidencebased practice and inform patients physicians guideline
Managing the health effects of climate change The Lancet ~ Effects of climate change on health will affect most populations in the next decades and put the lives and wellbeing of billions of people at increased risk During this century earths average surface temperature rises are likely to exceed the safe threshold of 2°C above preindustrial average temperature Rises will be greater at higher latitudes with mediumrisk scenarios predicting 2–3
Clinical judgement and the medical profession ~ Clinical judgment is a central element of the medical profession essential for the performance of the doctor and potentially generating information also for other clinicians and for scientists and health care managers The recently renewed interest in clinical judgement is primarily engaged with
Translating research findings to clinical nursing practice ~ Aims and objectives To describe the importance of and methods for successfully conducting and translating research into clinical practice Background There is universal acknowledgement that the
Clinical trial Wikipedia ~ Clinical trials are experiments or observations done in clinical prospective biomedical or behavioral research studies on human participants are designed to answer specific questions about biomedical or behavioral interventions including new treatments such as novel vaccines drugs dietary choices dietary supplements and medical devices and known interventions that warrant
The COMET Handbook version 10 Trials Full Text ~ The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly For the findings to influence policy and practice the outcomes need to be relevant and important to key stakeholders including patients and the public health care professionals and others making decisions about health care
Clinical features and multidisciplinary approaches to ~ Dementia is a clinical syndrome of widespread progressive deterioration of cognitive abilities and normal daily functioning These cognitive and behavioral impairments pose considerable challenges to individuals with dementia along with their family members and caregivers
Appraisal Tools for Clinical Practice Guidelines A ~ Clinical practice guidelines can improve healthcare processes and patient outcomes but are often of low quality Guideline appraisal tools aim to help potential guideline users in assessing guideline quality We conducted a systematic review of publications describing guideline appraisal tools in
Fundamental nursing care A systematic review of the ~ 31 Eligibility criteria We included experimental studies on any intervention undertaken by either professionally qualified andor unregistered nurses for people in hospital or resident in carenursing homes that aimed to address and measure the impact on participants nutrition elimination mobility and hygiene needs
Assessing Clinical Reasoning Targeting the Higher Levels ~ Clinical reasoning is the “thinking and decision making processes associated with clinical practice” 1 It involves pattern recognition knowledge application intuition and probabilities It is integral to clinical competency and is gaining increasing attention within medical education
